The Naked Attraction host revealed the tragic news on Twitter, saying her "heart hurts" from the loss.
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She wrote: "It hurts my heart to say my lovely Uncle Geoff has lost his fight against Covid-19. The family are raising money for the NHS staff who tried so hard to save him in ICU.
"Please…if you have a spare £… donate. We’re all in this together."
The 49-year-old then shared a link to a page raising funds for the East Kent Hospitals Charity Appeal.
Geoff was admitted to hospital on April 6 after feeling sick for a few days.
He eventually developed pneumonia as result of coronavirus and passed away on April 13.
The fundraising page launched by his family praised the NHS staff who had looked after him.
They wrote: "The paramedics, doctors and nurses that cared for him under these extremely difficult circumstances were absolutely amazing and we can't thank them enough for all they did.
"Donations will support the physical and emotional wellbeing of staff through this difficult time and provide vital additional equipment and much more."
Anna's fans rushed to share their condolences with her on Twitter.
One Twitter user wrote: "Sorry to hear that Anna. When it's a loved one it becomes so much more real."
Another said: "So very sorry for your loss Anna. This virus needs to be stopped now. My deepest condolences."
While a third wrote: "I obvs don't know you but have watched many of your programmes. Sending sympathies and sorry for your loss to all of you at this time."
Anna who is in a relationship with fellow TV host Sue Perkins took the time to reply to her fans.
She admitted the ordeal was very difficult and that "not even an oatcake can cheer me up".
Britain remains in lockdown in an attempt to slow the rate of new coronavirus cases.
The country currently has 120, 067 cases of coronavirus and 16,060 fatalities.
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